Our finding that minocycline reduces circulating levels of IL-6 is consistent with previous work showing that minocycline treatment supresses IL-6 expression in ovarian cancer cells66 and in the central nervous system, acting as a neuroprotective agent.67,68 However, future studies are needed to elucidate the molecular pathways by which minocycline decreases IL-6 expression. Here, IL6 is linked to ovarian carcinoma.