NPPB and heart failure: Compared with those not receiving a diuretic, patients in the highest diuretic dose category (>40 mg) were younger; had worse symptoms, functional class, and renal function; had higher NT-proBNP levels and body mass index and lower left ventricular ejection fraction and systolic blood pressure; and were more likely to have a history of heart failure hospitalization, atrial fibrillation, and diabetes mellitus.