Because sodium-glucose cotransporter 2 (SGLT2) reabsorbs sodium, in addition to glucose, in the proximal renal tubule, SGLT2 inhibition leads to natriuresis, as well as an increase in urinary glucose and accompanying water excretion.1 Consequently, SGLT2 inhibitors have a diuretic action in healthy volunteers and in individuals with type 2 diabetes mellitus. This evidence concerns the gene SLC5A2 and diabetes mellitus.