27 Ghalandari Ghalandari H H Hosseini-Esfahani Hosseini-Esfahani F F Mirmiran Mirmiran P P The association of polymorphisms in leptin/ leptin receptor genes and ghrelin/ghrelin receptor genes with overweight/obesity and the related metabolic disturbances: A review The association of polymorphisms in leptin/ leptin receptor genes and ghrelin/ghrelin receptor genes with overweight/obesity and the related metabolic disturbances: A review Int J Endocrinol Metab Int J Endocrinol Metab 2015 2015 13 13 e19073 e19073 10.5812/ijem.19073v2 10.5812/ijem.19073v2 26425125 26425125. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.