22 Manríquez Manríquez V V Avilés Avilés J J Salazar Salazar L L Saavedra Saavedra N N Serón Serón P P Lanas Lanas F F Polymorphisms in genes involved in the leptin-melanocortin pathway are associated with obesity-related cardiometabolic alterations in a Southern Chilean population Polymorphisms in genes involved in the leptin-melanocortin pathway are associated with obesity-related cardiometabolic alterations in a Southern Chilean population Mol Diagn Ther Mol Diagn Ther 2018 2018 22 22 101 101  13  13 10.1007/s40291-017-0306-8 10.1007/s40291-017-0306-8 28975585 28975585. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.