Interestingly, it has been reported that only the PX domain–containing TKS5α can contribute to metastasis and invadopodia formation in lung adenocarcinoma (Li et al., 2013), raising the questions whether and how Hs578T cells can form functional invadopodia in the absence of the highest molecular weight TKS5α isoform, and whether TKS4 could substitute. Here, SH3PXD2B is linked to lung adenocarcinoma.