In addition, we found that the defective polarization of MT1-MMP-positive LE/Lys impairs the degradative and invasive potential of breast cancer cells in 3D collagen, probably by interfering with MT1-MMP recycling from storage LE/Lys compartments to the invadopodial plasma membrane (Infante et al., 2018). The gene discussed is MMP14; the disease is breast carcinoma.