GRIA2 and Creutzfeldt Jacob disease: Supporting this, in CJD and PG14 PrP-expressing HeLa cells GluA2 had a perinuclear/reticular distribution, indicative of ER retention, which largely overlapped with PrP, whereas in FFI PrP-expressing cells GluA2 did not co-localize with intracellular PrP and was efficiently delivered to the plasma membrane.