In human glioblastoma U87 and U251 cells, EGFR activation leads to c-Src stimulation and subsequent Y59-Cdc25A phosphorylation, which dephosphorylates pyruvate kinase (PKM2), promoting its interaction with β-catenin, its transactivation and Myc transcription that induces Glut-1 (glucose transporter 1), PKM2 and LDHA expression and, consequently, the Warburg effect and tumorigenesis [18]. Here, PKM is linked to glioblastoma.