MCL1 and central nervous system cancer: For instance, imperatorin, a linear furanocoumarin compound extracted from the root of Angelica dahurica, has been reported to decrease the cisplatin resistance through suppression of MCL-1 [35]; Quercetin, a flavonoid that widely distributes in plant-based foods, has been found to reverse the resistance of prostate cancer to doxorubicin-based therapy [36]; Resveratrol, a natural polyphenol compound, has been proved to restore the sensitivity of glioma cells to temozolamide through inhibiting the activation of Wnt signaling pathway [37].