A few years later, Uldrijanet al. (Figure 2, Table 1) demonstrated thatenoxacin at 156 μM also displayedantitumor effects on human melanoma cell lines during a five-day treatment.35 Enoxacin was effective regardless of commonmutations in melanoma cells such as on BRAF kinase or NRAS oncogene.In the same article, by using A375 cells with enoxacin, the authorsperformed an Affymetrix GeneChip miRNA assay containing 5706 probesets and observed that it was able to modify the expression levelsof 55 maturated miRNAs, in particular upregulating 26 of them. Here, NRAS is linked to melanoma.