The available information indicates that these trials will investigate the pairing with checkpoint blockade therapy targeting the PD-1/PD-L1 axis with either pembrolizumab or avelumab in recurrent GBM as well as in CNS metastases from melanoma, non-small cell lung carcinoma (NSCLC), and renal cell carcinoma. Here, CD274 is linked to non-small cell lung carcinoma.