These studies provide insights into the regulatory mechanisms of the Nav1.6 channel by a relevant accessory protein, FGF14, which could have implications for diagnostic and therapeutic development against channelopathies associated with Nav1.6 and FGF14 (Di Re et al., 2017; Hoxha, Balbo, Miniaci, & Tempia, 2018; Meisler, Kearney, Escayg, Macdonald, & Sprunger, 2001; O'Brien & Meisler, 2013). Here, SCN8A is linked to channelopathy.