PLCG2 and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation: With regard to patient 2 who carried the missense p.Ala708Pro PLCG2 variant, his immunological phenotype (low IgM and B cell count and decreased circulating class-switched memory B cells) could be classified as mild-to-moderate and displayed marked similarities with the phenotype of the first described APLAID family carrying the missense p.Ser707Tyr PLCG2 variant [7].