CSCs in CRC are identified via a group of surface markers, such as CD44, CD133, ANXA2, CD24, DCLK1, Lgr5, ALDH1, Nanog, Oct-4, SOX-2, and EpCAM (Leng et al. 2018) (Gzil et al. 2019a, b). The gene discussed is CD44; the disease is colorectal carcinoma.