LGR5 and colorectal cancer: The overexpression of Lgr5 in the colorectal cancer cells occurs due to up or downregulation of several noncoding RNAs, such as CASC15 miR-4310 or miR-23a, as a consequence of activation of PI3K/Akt signaling pathway (Takahashi et al. 2011; Mukohyama et al. 2017).