MKI67 and colorectal carcinoma: From the previous studies on CRC, it is known that Lgr5 enhances downstream Wnt/β-catenin signaling and Lgr5+ cells exhibit a high ability of colony formation, self-renewal, differentiation, and Ki67 proliferative index (Fan et al. 2010; Takahashi et al. 2011; He et al. 2014; Leng et al. 2018; Zheng et al. 2018; Salehizadeh et al. 2019).