On the other hand, Lgr5- subpopulation of CRC CSC seems to be characterized by a higher expression of mesenchymal-associated genes such as Snail, Slug, Zeb1 and 2, and N-cadherin, and by a lower expression of epithelial-associated genes such as E-cadherin, occluding, and epithelial cell adhesion molecule (EpCAM) (Leng et al. 2018). This evidence concerns the gene CDH2 and colorectal carcinoma.