LGR5 and neoplasm: A similar conclusion of a high level of Lgr5 is an unfavorable factor with a shorter OS and disease-free survival (independent from tumor size) was also given in many other studies (Takahashi et al. 2011; Wu et al. 2012, 2016; Hsu et al. 2013; Jiang et al. 2015; Nishioka et al. 2018).