This suggestion could explain why a weak expression of Lgr5 in CRC correlate with lymph-node metastasis (high population of present Lgr5- CSC at the time of diagnosis) and its high level with worse overall survival (the detection of all cells, which might transform into metastatic-related chemo-insensible clone). Here, LGR5 is linked to metastatic malignant neoplasm in the lymph nodes.