The recently identified high-risk variants such as BRCA1 Associated Protein 1 (BAP1), Protection of Telomeres Protein 1 (POT1), Adrenocortical Dysplasia (ACD), Telomeric Repeat-binding Factor-2 Interacting Protein (TERF2IP), and Telomerase Reverse Transcriptase (TERT) contribute to about 2% of melanoma's missing heritability [36]. This evidence concerns the gene POT1 and melanoma.