The SECOMBIT is a randomized comparative three-arm study, which explores combined immunotherapy (Ipilimumab plus Nivolumab) followed by targeted combination therapy (Encorafenib plus Binimetinib) or vice versa in patients with metastatic mutated melanoma with BRAF; its design includes an 8-week induction with the targeted combination therapy, followed by combination immunotherapy, and subsequently by the target combo to progression [114, 115]. This evidence concerns the gene BRAF and melanoma.