Notably, PMNs from NASH patients, conversely respect to healthy donors and NAFL, when cocultured with PBMCs, acquired a strong active phenotype as revealed by the shedding of CD62L, the upregulation of CD11b (Figure 3(b)) and the increased intracellular production of ROS [50] (Figure 4(a)). This evidence concerns the gene ITGAM and metabolic dysfunction-associated steatohepatitis.