IL1B and autoimmune polyendocrinopathy: Our hypotheses were: (1) ACS and APS obtained from the same horses will have a different cellular and cytokine profile, (2) IL-1β would produce an inflammatory response in the co-cultured articular cartilage and synovial tissue, (3) TA would reduce expression and production of inflammatory proteins more effectively than orthobiologics (ACS and APS), but orthobiologics would protect matrix gene expression more effectively than TA.