In another report, antibody mediated topical inhibition of receptor for advanced glycation end products (RAGE) signaling showed reduced number of neutrophils in diabetic wounds in association with enhanced phagocytosis by Mφ and improved wound healing further supporting the notion that increased neutrophil accumulation in diabetic wounds results from reduced phagocytic ability of Mφ which is closely associated with impaired wound healing in diabetes (Figure 1C) (Wang et al., 2017). This evidence concerns the gene AGER and diabetes mellitus.