For example, in Spinal Muscular Atrophy, the genes Plastin-3 (PLS3) and Coronin 1C (CORO1C) were identified as protective modifiers, unraveling impaired endocytosis as a rescue mechanism for the phenotype (Hosseinibarkooie et al., 2016). Here, CORO1C is linked to spinal muscular atrophy.