We also found that in miR-223-null CD11b+ cells from the retina, there was increased C1qa which is associated with progressive retinal degeneration (Silverman et al., 2016; Jiao et al., 2018), as well as increased Stat3, also associated with retinal disease (Chen et al., 2016, 2019). This evidence concerns the gene C1QA and retinal degeneration.