SOCS1 and Hypertension: SOCS1 is expressed by immune cells, SOCS1 protein modulated inflammatory signaling (Metcalf et al., 2002; Davey et al., 2006), and it has been shown to be associated with hypertension via the JAK-STAT pathway (Ortiz-Munoz et al., 2010; Satou et al., 2012).