A recent report suggested that CaSR suppresses the malignant behavior of colonic cancer cells by regulating the Wnt signaling pathway including GSK3β and Cyclin D1 (Aggarwal et al., 2015), which was proved to be vitally important in the development and the growth of LUAD in previous studies, including ours (Li et al., 2008; Yang et al., 2015). Here, CASR is linked to malignant colon neoplasm.