Consistent regulation of Wnt pathway including GSK3β and Cyclin D1 by CaSR had been addressed in a previous study about colon cancer (Aggarwal et al., 2015) in which the authors observed upregulated GSK3β mRNA expression, reduced Cyclin D1, and decreased β-catenin nuclear translocation in HT29CaSR cells (colon cell line HT29 overexpressing the CaSR), and verified that the inhibition of the Wnt signaling was responsible for decreased invasive potential of HT29CaSR cells. This evidence concerns the gene CASR and colonic neoplasm.