OTULIN and hepatocellular carcinoma: In line with these observations in systemic, inducible Otulin or Birc2/3 knock-out mice, hepatocyte specific deletion of Otulin results in hepatocyte apoptosis with resultant compensatory hyperplasia and inflammation that can progress to hepatocellular carcinoma (Damgaard et al., 2020; Verboom et al., 2020).