RIPK1 and skin disorder: Cpdm mice that express catalytically inactive RIP1K45A do not develop dermatitis or systemic inflammation (Berger et al., 2014), and treatment with a RIP1 inhibitor, even starting at 6 weeks of age when there is disease induction, provides significant amelioration of the dermatitis and reduces immune infiltrates in the liver (Webster et al., 2020).