Interestingly, while dermatitis appears to be solely driven by TNFR1 signaling in SHARPIN deficient mice, loss of TNFR1 only delays the onset of dermatitis to approximately 70 days, which appears to be due to concurrent signaling through other death receptors including TNF-related apoptosis inducing ligand (TRAIL) receptor and CD95. Here, SHARPIN is linked to skin disorder.