These cytokines mediate the potentiation of keratinocytes on psoriatic inflammation, and the use of antibodies against IL-23, TNF-α, and IL-17 in the treatment of psoriasis has shown a key role of these cytokines in the pathogenesis of psoriasis (Lowes et al., 2014; Harden et al., 2015). The gene discussed is IL23A; the disease is psoriasis.