Previously, the effect of 31 (3-α-acetyl-11-keto-β-Boswellic acid) was studied on activated dendritic cells in psoriasis-like mouse model that revealed that this compound improved the psoriasis-like skin lesions, reduced the thickness of epidermis, ameliorated the infiltration of CD3+ and CD11c+ cells in skin lesions, decreased the activation of local dendritic cells, inhibited the expression and secretion of IL-12 and IL-23, inhibited the maturation and differentiation of DCs to promote T-cell differentiation, and inhibited the activation of TLR7/8 and IRF signaling pathways. This evidence concerns the gene TLR7 and psoriasis.