In a recently published pediatric cohort of 116 MOG-IgG seropositive patients, 4/6 children with an NMOSD phenotype had associated brain MRI findings, and 68 additional patients showed an encephalopathic presentation, including 64 with acute disseminated encephalomyelitis (ADEM) features and 22 satisfying criteria for autoimmune encephalitis without ADEM features (34). The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.