The focal adhesion kinase PTK2, a gene in the core of the Focal Adhesion pathway, and its central activator fibronectin 1 (FN1), as well as upstream integrin subunits ITGB1, ITGB3, and ITGA5, paxillin (PXN), and thrombospondin 1 (THBS1) represented hub nodes next to the common cancer associates VEGFA and EGFR, and all these genes are part of the Focal Adhesion pathway. The gene discussed is PTK2; the disease is cancer.