Nowadays, the agonist of PPAR gamma (PPARγ) is promising treatment for neuroinflammation-related condition eg. Alzheimer's disease, Parkinson's disease, and stroke (Govindarajulu et al., 2018; Wen et al., 2018; Lee et al., 2019). The gene discussed is PPARG; the disease is early-onset autosomal dominant Alzheimer disease.