FASN and cancer: There are reports supporting increased FASN activity and expression in various human cancers such as breast cancer (167–169), thyroid cancer (170), ovarian cancer (171), prostate cancer (172, 173), oral cancer (174–176), colorectal cancer (177), endometrial metastatic cancer (178) and in mesothelioma (179), renal cancer (180), and retinoblastoma (181, 182).