Giovannini et al. suggested that miR-199a-3p down-regulation is a common characteristic of HCC and that miR-199a-3p regulates E-cadherin expression through Notch1 (31), Jia et al. reported that miR-199a-3p represses tumorigenesis in HCC by targeting HIF-1α (32). This evidence concerns the gene HIF1A and hepatocellular carcinoma.