Univariate analysis showed that expression of SPARC, neutrophil-lymphocyte ratio (NLR), tumor diameter, lymph node metastasis, portal vein tumor thrombosis, as well as BCLC and TNM staging exhibited a correlation with the OS of patients with HCC undergone TACE (p < 0.05, Table 2). The gene discussed is SPARC; the disease is metastatic malignant neoplasm in the lymph nodes.