The miR-15/107 family is found to have target sites within circRNAs from host genes CDC42, MGEA5, CHPT1, GPATCH2L, TSEN2, RPL14, PLD1, TFRC, PDLIM5, and PTK2. The genes CDC42, PLD1, and PTK2 are involved in the EGFR signaling pathway; the miR-15/107 family is reported to have tumor suppressor properties (34, 39), and the circRNAs from the above genes for EGFR signaling pathway can act as “sponges” to exert oncogenic effect in the context of NMIBC. The gene discussed is PLD1; the disease is neoplasm.