However, in the ERα-positive MCF-7 breast cancer cell line, possessing the well-identified close cross-talk between AhR and ERα [for review (75)], 10−5 M G1 was demonstrated to increase transcription of CYP1A1 mRNA in AhR-dependent, but GPR30-independent, mechanisms (76). The gene discussed is ESR1; the disease is breast carcinoma.