Similarly, SASH1 overexpression inhibits the proliferation and invasion of thyroid cancer cells by suppressing the phosphorylation of PI3K and AKT (43), inhibits the invasion and metastasis of hepatocellular carcinoma cells by suppressing PI3K/AKT signaling pathway (44), and suppresses the TGF-a1-induced EMT of stomach cancer cells by suppressing the phosphorylation of PI3K and AKT (45). This evidence concerns the gene AKT1 and thyroid cancer.