Additionally, most of immunotherapeutic reagents show outstanding anti‐tumor effect when only it combined with chemotherapeutic and other immunotherapeutic.[17, 30] Based on the chemo‐sensitization effect and immune checkpoint function of HO1,[17] T‐hNP/SnMP was combined with DNR in human AML‐bearing orthotopic model. This evidence concerns the gene HMOX1 and acute myeloid leukemia.