Collectively, HO1‐inhibiting T‐hNP reprogrammed bone marrow myeloid cells by recruiting Gr1‐int, Ly6c‐int, F4/80‐int monocytic cells, inducing F4/80‐hi, CD206‐ M1‐like macrophages, consequently, enhances the immune activation response against apoptotic leukemia cells. Here, MRC1 is linked to leukemia.