Previous studies have demonstrated chemo‐resistant effect of HO1 in various cancers and AML.[13, 14] Recently, we have reported that siRNA‐mediated HO1 inhibition enhances chemo‐sensitivity in an AML xenograft model and patient‐derived cells.[15] To evaluate the chemo‐sensitization effect of HO1‐inhibiting hNPs, THP‐1, and U937 cells were treated with empty‐ and SnMP‐loaded T‐hNPs in the presence of daunorubicin (DNR), a first‐line chemotherapeutic for AML. Here, HMOX1 is linked to acute myeloid leukemia.