As classical T cell maturation process, CD4/CD8 double positive T cells were well‐described naïve T cells within thymus.[11] Although DPT cells in blood and peripheral lymphoid tissues have been widely studied, their molecular features and cellular functions in cancers are unclear.[22] Based on CyTOF data, as shown in Figure S6A (Supporting Information), the 3D diffusion plots had two major branches (T cell clusters were labeled according to the above results by FlowSOM analysis). This evidence concerns the gene CD8A and cancer.