In mice, fructose also stimulated the expression of 12-lipoxygenase (12-LOX) and the production of the arachidonate metabolite 12-hydoroxy-5Z,8Z,10E,14Z-eicosate-traenoic acid (12-HETE) production, thereby implicating fructose in inducing 12-LOX signaling to increase the risk of breast cancer development and its metastasis [66]. This evidence concerns the gene ALOX12 and breast cancer.