For the co-receptor CXCR4, Hou et al. has proven that the disruption of CXCR4 by CRISPR/SpCas9 in genome level confers the edited cells resistant to HIV-1(X4-strains) infection and no obvious effects on off-target and proliferation, Wang et al. has verified the phenomenon with CXCR4 modification by CRISPR/SaCas9 [20, 24]. The gene discussed is CXCR4; the disease is infection.