Several studies associated with CCR5 ablation by CRISPR/Cas9 have been reported recently, for example, Xiao et al. have reported that the CRISPR/SaCas9, a Cas9 version from Staphylococcus aureus, could efficiently edit the CCR5 in different cell types including human CD34+ hematopoietic stem/progenitor cells, and the results in humanized mice have clarified that CCR5 disruption via lenti-CRISPR/SaCas9 renders CD4+ T cells survival from HIV-1 infection [33]. Here, CCR5 is linked to HIV-1 infection.