MYC and leukemia: Inhibition of the activity of fat and obesity-related protein (FTO) by R-2-hydroxyglutaric acid (R-2HG) increases the overall m6A level in R-2HG sensitive leukemia cells which in turn decreases the stability of MYC/CEBPA transcripts, leading to suppression of MYC/CEBPA-related signaling pathways and thus inhibition of the proliferation of FTO-highly expressed cancer cells [40].