AKT1 and obesity due to melanocortin 4 receptor deficiency: The aim of this study was to investigate the gene expression pattern of PI3K/AKT pathway in obese and non-obese metabolically healthy individuals and compare this pattern with obese and non-obese diabetics to propose molecular mechanistic insights into how differential regulation of PI3K/AKT pathway is responsible for obesity heterogeneity in Type II diabetes.