The top 10 most significant DEmRNAs were GABRD, THBS4, COL15A1, CDKN3, KIF4A, SLC26A6, PLVAP, CDCA5, KIF2C, and KIFC1, and subsequent analysis of these genes revealed that some play an important role in HCC. This evidence concerns the gene PLVAP and hepatocellular carcinoma.