ANOS1 and Anosmia: Anosmin-1 is largely present in different structures of the central nervous system, including the cerebral cortex, olfactory bulb, and other components of the olfactory system, and when mutated in KS may lead to satellite symptoms including anosmia and HH (García-González et al., 2016; de Castro et al., 2017; Stamou and Georgopoulos, 2018).