VCX3A, only expressed in male germ cells, may mediate sperm production, whose defect is associated with XLI and may be associated with intellectual disability (Van Esch et al., 2005; Cuevas-Covarrubias and González-Huerta, 2008; Khelifa et al., 2013). Here, VCX3A is linked to recessive X-linked ichthyosis.