In addition to the interactions between HLA-G and its receptors, HLA-G-mediated immunosuppression by intercellular transfer mechanisms such as trogocytosis, exosomes, or tunneling nanotubes (TnTs) also represents another important complementary mechanism through which cancer cells escape destruction by the host immune system (11, 12, 79–81). The gene discussed is HLA-G; the disease is cancer.