SOCS1 and arthritic joint disease: We observed that from the four SNPs whose minor allele was associated with low SOCS1 expression, two were also linked to a higher odds ratio of RA diagnosis (p < 0.150), and one of these two (rs4780355) was linked to poor response (p < 0.150) (Supplementary Table 6), suggesting that this SNP might predict a poorer clinical course in patients with early arthritis.