Data from the independent early, drug-naïve, Leeds RA cohort (n = 74) treated according to the treat-to-target protocol (i.e., the achievement of remission (24) with synthetic DMARDs (methotrexate dose escalation) confirmed that low SOCS1 baseline expression was associated with inability to achieve remission at 6 months (Table 3, p = 0.036). Here, SOCS1 is linked to rheumatoid arthritis.