In a study on AOM/DSS-induced colorectal cancer, the number and size of tumors were found to increase in IL-22−/− mice compared to WT mice, while the IL-22BP−/− mice were found to exhibit increased tumorigenesis in an NLRP3/NLRP6-IL-18-dependent manner (134), indicating that IL-22 can protect mice against tumor development. Here, IL22 is linked to infectious otitis media.