(b) significant sex differences in AM gene expression of SP-A2 (1A3), SP-A2 (6A2, 6A4), and SP-A-KO mice at 6 h post-infection; (c) of the three pathways (TNF, TP-53, and cell cycle signaling nodes) studied here, all variants except SP-A2 (1A3) female, showed significance for at least 2 of these pathways, and KO male showed significance for all three pathways; (d) though the expression profile of validated genes was variant-specific, a similarity in the gene expression profile of KO and SP-A1 mice was observed. Here, TNF is linked to infection.