Moreover, other genes such as CCNA1, CCND1, IRF1, NKX3-1, PPARA, RAG1, TIE1, CDK1, MMP12, MYC, STAT5a/b, CDKN1A and TCF4 that are part of the cell cycle node had sex and variant-specific differential gene expression changes in response to infection. The gene discussed is TIE1; the disease is infection.