A similar analysis of the genes identified, from males and females of SP-A1 (6A2, 6A4), SP-A2 (1A3) variants, and KO, whose expression was ≥2-fold in response to infection also showed the association of genes with TP53, TNF, and cell cycle signaling nodes with direct (solid lines) and indirect (dashed lines) (Supplementary Figure 3) indicating that among SP-A variants these pathways may be differentially activated and to a varying degree in response to infection. Here, TP53 is linked to infection.