Moreover, in mice models of NASH, the overexpression of adhesion molecules ICAM-1, VCAM-1, and vascular adhesion protein-1 (VAP-1) in LSECs were critical for the adhesion and transmigration of monocytes to amplify local inflammatory response (14, 85, 86). This evidence concerns the gene AOC3 and metabolic dysfunction-associated steatohepatitis.