To study the expression of HMGB1 redox isoforms in tumors and cachectic muscles, we employed two well-established mouse models of cancer cachexia: C57BL/6 and BalB/C mice injected subcutaneously with Lewis Lung Carcinoma (LLC) cells and colon adenocarcinoma C26 cells, respectively. The gene discussed is HMGB1; the disease is cancer.