In a metastatic setting, of 159 patients analyzed for TILs based on IHC, none of the T-cell subsets alone (CD8, CD4, TReg) were associated with tumor response, but a low TReg/CD8+ ratio was associated with more tumor response to platinum doublets in multivariate analysis [odds ratio = 4.17, 95% confidence interval (CI) = 1.02–13.37, p = 0.029] (75). This evidence concerns the gene CD4 and neoplasm.