Although it has been shown that methylation of HIF1α protein by methyltransferases G9a and GLP prevents HIF1α protein accumulation in neuroblastoma cells (71), it is still unknown whether HIF1α downregulation during the contraction phase is also mediated via increased G9a/GLP-dependent HIF1α protein methylation. The gene discussed is HIF1A; the disease is neuroblastoma.