It was reported that lactoferrin (Lf), lysozyme (Lz), human beta defensin 2 (HBD2), human alpha defensin 5 (HD5), and human alpha defensin 1 (HNP1) are capable of inhibiting microsporidian spore germination and reducing enterocytes infection (Leitch and Ceballos, 2008). This evidence concerns the gene DEFA5 and infection.