For example, mPRα mediates oocyte meiotic maturation and sperm motility in fish, anti-apoptosis in fish ovarian granulosa cells and in human breast cancer cells (32, 33), relaxation of human myometrial and vascular muscle cells (34, 35), reversal of epithelial to mesenchymal transition in breast cancer cells (36), and inhibition of prolactin release from rat lactotrophs through activation of TGFβ1 (37). The gene discussed is TGFB1; the disease is breast cancer.