In our study, we indicated that dietary ALA-rich FO alleviated systematic and ovarian inflammation via suppressing the pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-17A, and MCP-1) and elevating the anti-inflammatory IL-10, suggesting the anti-inflammation role of inexpensive dietary FO administration in PCOS. This evidence concerns the gene IL1B and polycystic ovary syndrome.